مجله دانشکده پزشکی زابل
سال چهارم شماره 2 (پیاپی 11، تابستان 1400)

Breast cancer is one of the most malignant cancersin the world. Cold micro plasma jet (CMPJ) Known as cold atmospheric jet microplasma, it has recently been introduced as an alternative way to overcome the challenges of finding an effective cancer treatment. Numerous studies have reported promising results, so our aim of this study was to investigate how this method affects cell death and its role on the expression of apoptotic genes in the MCF-7 cancer cell line.

In this study, helium gas was used to generate plasma at room temperature in the form of point radiation at different times of 30, 60, 90 and 120 seconds and at different distances of 1 cm. Flow cytometry will be used to examine the extent of apoptosis andnecrosis. Genes involved in apoptosis P53, P21, Bax and Bcl-2 were measured by real-time PCR.

Our Studie indicate that the mechanism of action of cold plasma on cancer cells is related to generation of reactive oxygen species with possible induction of the apoptosis pathway. The percentages of necrotic and late apoptotic cells following treatment with different times plasma (0, 30, 60, 90 and 120 s) were about 0.55 ± 0.06, 20.13 ± 0.01, 20.12 ± 0.03, 26.81 ± 0.04 and 17.51 ± 0.05. The mRNA expression of bcl-2 showed a decrease of 90s of plasma while the mRNA expression of p53, bax and caspase-8 genes increased compared to untreated cells.

In general, research in the last decade has confirmed the ability of CMPJ as an effective anti-cancer tool. Therefore, it may be used to help treat cancer. However, its clinical application requires much further studies to determine the severity and duration of exposure to CMPJ for effective treatment based on the type of cancer.

Nutrition is one of the most contributing factors in health that can affect different aspects of human life. Today because of changing in lifestyle and unhealthy dietary patterns, there is augment in the incidence of obesity, chronic disease and mental disorders like depression. In this study, we have investigated the prevalence of depression and dietary patterns in the students of Zabol University of Medical Sciences.

A descriptive cross-sectional study carried out on 313 students of Zabol city usingsimple random sampling in 2019.

The prevalence of depression in studied students was 58%. Two major dietary patterns were identified: the healthy dietary pattern and the unhealthy dietary pattern. After adjusting confusing variables, individuals who gained higher scores in unhealthy dietary pattern, had higher probability (OR = 2.19, 95%CI: 1.10 to 4.36, p value = 0.02) of depression, however healthy dietary patterns showed no significant association with the risk of depression.

Findings indicate a higher prevalence of depression and positive relationship between unhealthy dietary patterns with the risk of depression in studied students.

Addiction as achronic disorder that requires long treatment. One way to treating this chronic disease is exercise. Chronic exposure to opiates impairs spatial learning and memory. Given the well-known beneficial effects of voluntary exercise on cognitive functions, we investigated whether voluntary exercise would ameliorate the cognitive deficits that are induced by morphine dependence. If an effect of exercise was observed, we aimed to investigate the possible role of hippocampal brain-derived neurotropic factor (BDNF)in the exercise-induced enhancement of learning and memory in morphine-dependent rats.

The rats were injected with bi-daily doses (10 mg/kg, at 12 hr. intervals) of morphine over a period of 10 days of voluntary exercise. Following these injections, a water maze task was performed twice a day for 5 consecutive days, followed by a probe trial 2 days later. A specific BDNF inhibitor (TrkB-IgG chimera) was used to block the hippocampal BDNF action during the 10 days of voluntary exercise.

The voluntary exercise diminished the severity of the rats’ dependency on morphine. A blockade of the BDNF action blunted the exercise-induced improvement of spatial memory, hippocampal neuron counting and BDNF protein levels in the dependent rats. Our results indicate that voluntary exercise could be increase the expression of LTP by lowering the induction threshold for LTP in the DG of morphine-dependent rats.

Thus, voluntary exercise might be considered as a potential method to ameliorate some of the deleterious behavioral consequences of the abuse of morphine and other opiates.

Since the Covid-19 virus its initial outbreak has caused many psychological problems for humans, the present study aims to done the relationship between cognitive anxiety and stress caused by Covid-19 virus with sleep quality in public society.

The present study was a descriptive correlational survey. The statistical population of the study included all the people of the country in 1399 through questionnaires that were placed electronically on popular sites, channels and people messengers, which finally 239 people answered the questionnaires. Research tools include; Alipour et al. Corona cognitive anxiety Questionnaire (2020), Lovibond & Lovibond Stress Questionnaire (1995), and Pittsburgh Sleep Quality Index (1989). After electronic collection of questionnaires, the obtained data were analyzed by descriptive statistics, Correlation coefficient, and Regression analysis simultaneously.

The results showed that cognitive anxiety and stress caused by Covid-19 have a significant relationship with sleep quality (p value < 0.001), so that both can predict 0.41 changes in sleep quality.

Therefore, it can be concluded that anxiety and stress caused by Covid-19 can predict the quality of sleep.

Failure to observe hygienic principles and making minor cuts with scissors and razors while applying makeup may lead to the transmission of diseases of blood origin. The aim of this study was to investigate the knowledge and attitude of female hairdressers in Rafsanjan regarding the prevention of Blood-borne diseases and its relationship with demographic characteristics in 2019-2020.

This cross-sectional study was performed in all hairdressing salons in Rafsanjan that had official activities, by census (201 hairdressers). The tool for measuring knowledge and attitude was a researcher-made questionnaire that was completed as a self-report. The questionnaires were anonymous and coded and included demographic information, awareness and attitude. Data were entered into SPSS software version 18 and reported by indices of Dispersion indices, frequency distribution and Pearson correlation coefficient.

The average knowledge and attitude of hairdressers about Blood-borne diseases were 57.95 ± 5.11 and 57.95 ± 11.35, respectively. There was a statistically significant relationship between the mean score of knowledge and attitude of the research samples with the level of literacy (p value = 0.001). Most of the research samples mentioned that there is a vaccine to prevent hepatitis C disease and it was believed that covering the needle head after use has no effect on Blood-borne diseases.

Considering the average level of knowledge of hairdressers, it is suggested that more effective training courses to increase the knowledge of hairdressers using different training methods in order to make more effectiveness of health programs.

Higher education has a fundamental role in the development of societies. The main elements in the university include professors, students and the educational environment. In this research, an attempt was made to review the educational quality of professors and the factors affecting in universities.

In this systematic review, the keywords of evaluation in the educational system, teacher evaluation, student evaluation, factors affecting teacher evaluation in SID, Magiran, PubMed, Science Direct, Scopus, Medline, Springer, Proquest databases in 2000 2019 to answer questions 5 several studies were used and finally 37 articles were selected and analyzed

The results of the studies showed that the most common method of evaluation of professors is by students. Some professors are dissatisfied with the evaluation by students because they consider it harmful and at a low leveland different courses are not evaluated differently. Criteria from the perspective of students and professors include motivating students, moral, behavioral, personality, professional, interpersonal and social relationships, educational and research activities, professional development, counseling and executive services, observance of educational rules, teaching methods and Scientific mastery and quality of teaching.

If the evaluation of educational quality in time and method and qualified people for evaluation, feedback to students, use of valid and reliable evaluation forms, accurate monitoring of evaluation are used, we will see an increase in review of teachers' educational activities.